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Veterinary Pathology, Vol 16, Issue 5 493-509, Copyright © 1979 by American College of Veterinary Pathologists

ARTICLES

Acid mucopolysaccharides in mammary tumors of dogs

T. E. Palmer and A. W. Monlux

The predominant acid mucopolysaccharides found in selected epithelial mammary tumors of dogs stained with alcian blue and were labile to hyaluronidase digestion. These histochemical characteristics identified them as hyaluronic acid, chondroitin-4- and chondroitin-6-sulfate. The intensity of the staining of these acid mucopolysaccharides varied in a transitionary process from a precartilaginous to a pseudocartilaginous intercellular matrix to mature hyaline cartilage. The tumor acid mucopolysaccharides were indistinguishable from those associated with formation of cartilage in developing mammals; such cartilage is reported to be produced only by cells of mesodermal origin. There was no evidence to suggest transitional changes in myoepithelial cells, neoplastic epithelial cells or their components that could contribute to the formation of the acid mucopolysaccharides. It was concluded that the heterotopic tissues (cartilage, bone and fibrous connective tissue) in the epithelial mammary tumors were derived from cells of mesodermal origin and formed the adjacent stroma in areas of neoplasia.


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A. Espinosa de los Monteros, M. Y. Millan, J. Ordas, L. Carrasco, C. Reymundo, and J. Martin de las Mulas
Immunolocalization of the Smooth Muscle-Specific Protein Calponin in Complex and Mixed Tumors of the Mammary Gland of the Dog: Assessment of the Morphogenetic Role of the Myoepithelium
Vet. Pathol., March 1, 2002; 39(2): 247 - 256.
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