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Veterinary Pathology, Vol 17, Issue 2 200-205, Copyright © 1980 by American College of Veterinary Pathologists

ARTICLES

Proliferative lesions of the spleen in male F344 rats fed diets containing P-chloroaniline

J. M. Ward, G. Reznik and F. M. Garner

Fifty male F344 rats were given diets containing 500 mg/kg P-chloroaniline. Controls received diets without the chemical. Eighteen of the dosed rats developed proliferative lesions of the spleen. Lesions included parenchymal fibrosis and fatty infiltration, well and poorly differentiated fibrosarcomas, osteosarcomas and hemangiosarcomas. All dosed rats had focal and diffuse fibrosis and papillary hyperplasia of the splenic capsule.


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 Toxicol PatholHome page
A. W. Suttie
Histopathology of the Spleen
Toxicol Pathol, August 1, 2006; 34(5): 466 - 503.
[Abstract] [Full Text] [PDF]


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