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Veterinary Pathology, Vol 18, Issue 1 62-70, Copyright © 1981 by American College of Veterinary Pathologists

ARTICLES

The ultrastructure of nephrocalcinosis induced in chicks by Cestrum diurnum leaves

K. Sarkar, R. Narbaitz, R. Pokrupa and H. K. Uhthoff

Powdered Cestrum diurnum leaves, mixed with two diets differing in calcium and phosphorus contents, produced nephrocalcinosis in young chicks regardless of serum calcium elevation. The calcific deposits, found in both proximal and distal portions of cortical tubules, began either in the cytoplasm or in lysosomal bodies as a unilaminar spheroid structure containing apatite crystals. The ultrastructural characteristics of intraluminal concretions suggested that they were formed intracellularly but later were extruded into the lumen. The extent of calcific deposits increased with duration and with hypercalcemia. Although Cestrum contains an analog of 1,25-dihydroxycholecalciferol, neither mitochondria nor basal lamina contained calcific deposits described in nephrocalcinosis secondary to hypervitaminosis D.




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Copyright © 1981 by the American College of Veterinary Pathologists.