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Veterinary Pathology, Vol 18, Issue 4 439-444, Copyright © 1981 by American College of Veterinary Pathologists


ARTICLES

Canine bile duct carcinoma

A. K. Patnaik, A. I. Hurvitz, P. H. Lieberman and G. F. Johnson

Twenty-four adenocarcinomas of the hepatobiliary system were found among 110 primary hepatic neoplasms: 22 of these were intrahepatic, one involved the extrahepatic bile duct and one the gall bladder. Histologically, 10 intrahepatic neoplasms were classified as cholangiocarcinoma, and 12 as bile duct cystadenocarcinoma. The former were characterized by tubular structures lined by anaplastic cuboidal or columnar cells with diffuse fibrous stroma, and the latter by multiple cystic structures with papillary and solid areas. Half the bile duct cystadenocarcinomas showed benign cysts and transition to adenocarcinomas. This was seen in only one case of cholangiocarcinoma. The extrahepatic bile duct carcinoma was characterized by tubular structures lined with flattened cuboidal cells with scant stroma. The gall bladder adenocarcinoma contained many acinar structures lined with columnar or cuboidal cells and separated by thin stroma. Distant metastasis was found in 87.5% (21 of 24) sites of metastasis.


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J. A. Ramos-Vara, M. A. Miller, and G. C. Johnson
Immunohistochemical Characterization of Canine Hyperplastic Hepatic Lesions and Hepatocellular and Biliary Neoplasms with Monoclonal Antibody Hepatocyte Paraffin 1 and a Monoclonal Antibody to Cytokeratin 7
Vet. Pathol., November 1, 2001; 38(6): 636 - 643.
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