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Veterinary Pathology, Vol 19, Issue 1 79-92, Copyright © 1982 by American College of Veterinary Pathologists

ARTICLES

Acute encephalitis and hydrocephalus in dogs caused by canine parainfluenza virus

W. K. Baumgartner, S. Krakowka, A. Koestner and J. Evermann

Gnotobiotic puppies were inoculated intracerebrally with a strain of canine parainfluenza virus (CPI-78-238). Four of eight dogs developed histological evidence of acute encephalitis. Clinical signs of encephalitis were seen in two of these four dogs; one had signs and lesions of interstitial pneumonia. Of six inoculated dogs observed for six months after infection, five developed internal hydrocephalus. Virus was reisolated from two dogs with acute encephalitis but not from dogs with hydrocephalus. Hemagglutination-inhibition antibodies persisted throughout the observation period of six months at high levels in the serum and cerebrospinal fluid of hydrocephalic dogs.


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Copyright © 1982 by the American College of Veterinary Pathologists.