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Veterinary Pathology, Vol 35, Issue 4 268-273, Copyright © 1998 by American College of Veterinary Pathologists

ARTICLES

Increased numbers of CD4+ and CD8+ T cells in lesional skin of cats with allergic dermatitis

P. J. Roosje, P. J. van Kooten, T. Thepen, I. C. Bihari, V. P. Rutten, J. P. Koeman and T. Willemse
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht, The Netherlands.

The aim of this study was to characterize T cells in the skin of cats with an allergic dermatitis histologically compatible with atopic dermatitis, since T cells play an important role in the pathogenesis of atopic dermatitis in humans. We observed a significantly greater number of T cells in lesional skin of domestic short-haired cats with allergic dermatitis (n = 10; median age 5.8 years) than in the skin of healthy control animals (n = 10; median age 5.0 years). In the skin of the healthy control animals, one or two CD4+ cells and no CD8+ cells were found. A predominant increase of CD4+ T cells and a CD4+/CD8+ ratio (mean +/- SD: 3.9 +/- 2.0) was found in the lesional skin of 10 cats with allergic dermatitis. The CD4+/CD8+ cell ratio in the skin of healthy control animals could not be determined because of the absence of CD8+ cells. The CD4+/CD8+ cell ratio in the peripheral blood of 10 cats with allergic dermatitis (mean +/- SD: 1.9 +/- 0.4) did not differ significantly from that in 10 healthy control animals (2.2 +/- 0.4). The CD4+/CD8+ cell ratio and predominance of CD4+ T cells in the lesional skin of cats with allergic dermatitis is comparable to that found in atopic dermatitis in humans. In addition, the observed increase of CD4+ T cells in the nonlesional skin of cats with allergic dermatitis compared to the skin of healthy cats is similar to what is seen in humans. Cytokines produced by T cells and antigen-specific T cells are important mediators in the inflammatory cascade resulting in atopic dermatitis in humans. This study is a first step to investigate their role in feline allergic dermatitis.


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P. J. Roosje, G. A. Dean, T. Willemse, V. P. M. G. Rutten, and T. Thepen
Interleukin 4-Producing CD4+ T Cells in the Skin of Cats with Allergic Dermatitis
Vet. Pathol., March 1, 2002; 39(2): 228 - 233.
[Abstract] [Full Text] [PDF]


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Copyright © 1998 by the American College of Veterinary Pathologists.