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Veterinary Pathology, Vol 36, Issue 6 616-618, Copyright © 1999 by American College of Veterinary Pathologists

ARTICLES

Reduced anchoring fibril formation and collagen VII immunoreactivity in feline dystrophic epidermolysis bullosa

T. Olivry, S. M. Dunston and M. P. Marinkovich
Department of Companion Animal and Special Species, North Carolina State University, College of Veterinary Medicine, Raleigh 27606, USA. Thierry_Olivry@ncsu.edu

Dystrophic epidermolysis bullosa was diagnosed in a cat with juvenile-onset epithelial sloughing of the oral mucosa, footpads, and haired skin. Dermoepidermal separation occurred in the absence of inflammation or cytolysis of basal epidermal cells. Collagen IV-specific immunostaining corroborated the fact that clefting took place below the epidermal basement membrane. Ultrastructural examination revealed that the proband's anchoring fibrils exhibited a filamentous morphology and were decreased in number compared with those in a normal cat. Finally, the attenuated immunoreactivity for collagen VII in our patient led us to suspect that its encoding gene, COL7A1, could be mutated in this case of feline dystrophic epidermolysis bullosa.


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K. A. Brenneman, T. Olivry, and D. C. Dorman
Rudimentary Hemidesmosome Formation in Congenital Generalized Junctional Epidermolysis Bullosa in the Sprague-Dawley Rat
Vet. Pathol., July 1, 2000; 37(4): 336 - 339.
[Abstract] [Full Text] [PDF]


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