This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Taniyama, H. Articles by Nagahata, H. Search for Related Content PubMed PubMed Citation Articles by Taniyama, H. Articles by Nagahata, H.

Systemic AL Amyloidosis Associated with Bovine Leukocyte Adhesion Deficiency

Abstract

Histopathologic and immunohistochemical examinations were conducted on a 5-year-old Holstein–Friesian cow with systemic AL amyloidosis associated with bovine leukocyte adhesion deficiency. Amyloid deposits were present in the perivascular and intercellular spaces of the visceral organs, such as the liver, kidneys, pancreas, adrenal glands, and upper alimentary tract. Amyloid was stained positively with Congo red with or without 5% potassium permanganate pretreatment and had green birefringence observed under polarized light. Immunohistochemically, amyloid reacted strongly against anti-bovine IgG (H+L) and anti-bovine -light chain and reacted weakly against bovine -light chain antibodies but was negative for anti-human amyloid AA antibody. This is the first description of AL amyloidosis immunohistochemically related to immunoglobulin -light chains of precursor protein in cattle.

Key words: Bovine leukocyte adhesion deficiency; cattle; immunohistochemistry; AL amyloidosis.

Request reprints from Dr. H. Taniyama, Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Bunkyodai-Midorimachi 582, Ebetsu, Hokkaido 069-8501 (Japan).

This article has been cited by other articles:

				D. Y. Kim, H. W. Taylor, S. C. Eades, and D.-Y. Cho Systemic AL Amyloidosis Associated with Multiple Myeloma in a Horse Vet. Pathol., January 1, 2005; 42(1): 81 - 84. [Abstract] [Full Text] [PDF]