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Vet Pathol 37:186-188 (2000)
© 2000 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Choriocarcinoma and Teratoma in the Ovary of a Cynomolgus Monkey

K. Toyosawa, K. Okimoto, T. Koujitani and E. Kikawa

Abstract

An ovarian choriocarcinoma was found in a 13-year-old cynomolgus monkey (Macaca fascicularis). The tumor was accompanied by a mature teratoma in the contralateral ovary. Histologically, the choriocarcinoma was characterized by nests of cells where cytotrophoblasts occupied the periphery with syncytiotrophoblasts at the center. Immunohistochemical staining for anti-human chorionic gonadotropin was positive in the syncytiotrophoblasts. The teratoma consisted of well-differentiated epidermal cells, sebaceous glands, hair follicles, cartilage, bone, and teeth. Choriocarcinoma metastases were in multiple organs. The concomitant development of choriocarcinoma and teratoma in the ovary is a consistent finding with the human counterparts of these lesions.

Key words: Choriocarcinoma; cynomolgus monkey; Macaca fascicularis; ovary; teratoma.

Request reprints from Dr. K. Toyosawa, Department of Toxicology, Developmental Research Laboratories, Dainippon Pharmaceutical Co., 33-94 Enoki, Suita, Osaka 564-0053 (Japan). E-mail: kaoru-toyozawa{at}dainippon-pharm.co.jp.




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