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Vet Pathol 37:268-271 (2000)
© 2000 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Immunohistopathologic Characterization of a Dermal Melanocytoma-Acanthoma in a German Shepherd Dog

A. Espinosa de los Monteros, J. Martín de las Mulas, A. Fernández, J. Orós and F. Rodríguez

Abstract

A cutaneous melanocytoma-acanthoma in a 2-year-old female German Shepherd Dog was characterized by the presence of two populations of neoplastic cells: epithelial and melanocytic. The epithelial component consisted of nests of well-differentiated stratified squamous epithelium closely associated with neoplastic melanocytes. The epithelial cells immunoreacted with both monoclonal and polyclonal anti-cytokeratin antibodies, and immunoreaction to S-100 protein and vimentin was observed in the melanocytic cells. This rare pigmented skin neoplasm of the dog apparently has a benign behavior.

Key words: Dogs; immunohistochemistry; melanocytoma-acanthoma; skin.

Request reprints from Dr. A. Espinosa de los Monteros, Departamento de Morfología, Facultad de Veterinaria, Universidad de Las Palmas de Gran Canaria, Trasmontaña, 35416 Arucas, Gran Canaria (Spain). E-mail: espinosa{at}cicei.ulpgc.es.






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