Vet Pathol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hirayama, K.
Right arrow Articles by Taniyama, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hirayama, K.
Right arrow Articles by Taniyama, H.
Vet Pathol 37:353-356 (2000)
© 2000 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

A Pleomorphic Adenoma of the Lacrimal Gland in a Dog

K. Hirayama, Y. Kagawa, K. Tsuzuki, T. Kotani, Y. Azuma, T. Yoshino and H. Taniyama

Abstract

A 13-year-old female mongrel dog had a pleomorphic adenoma of the lacrimal gland in the right upper orbit. The tumor measured 3.8 x 3.0 x 3.3 cm, appeared white, round, and firm, and pressed the right globe and surrounding tissues. Histopathologically, the tumor had a thin connective tissue capsule and was composed of tubules with two cell types, some resembling luminal epithelial cells making up the tubular structures and the other of myoepithelial cells. Epithelial tubules were disposed in an adenomatous fashion and separated from each other by proliferating pleomorphic myoepithelial cells. Immunohistochemically, large numbers of the luminal epithelial cells revealed an immunopositive reaction against keratin/cytokeratin (AE1/AE3), and some epithelial cells reacted against cytokeratin 14. Spindle-shaped myoepithelial cells revealed an immunopositive reaction against cytokeratin 14, {alpha}-smooth muscle actin, and vimentin. A small number of myoepithelial cells reacted against desmin. S-100 protein immunopositivity was frequently found in luminal epithelial cells and rarely in the pleomorphic myoepithelial cells. Glial fibrillary acidic protein positivity was commonly found in myoepithelial cells, myxoid matrices, and intracystic materials, but not in luminal epithelial cells.

Key words: Dogs; glial fibrillary acidic protein; lacrimal gland; tumor.

Request reprints from Dr. H. Taniyama, Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Bunkyodai-Midorimachi 582, Ebetsu, Hokkaido 069-8501 (Japan).




This article has been cited by other articles:


Home page
 Vet PatholHome page
K. Hirayama, Y. Honda, T. Sako, M. Okamoto, N. Tsunoda, M. Tagami, and H. Taniyama
Invasive Ductal Carcinoma of the Mammary Gland in a Mare
Vet. Pathol., January 1, 2003; 40(1): 86 - 91.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American College of Veterinary Pathologists.