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Vet Pathol 37:472-475 (2000)
© 2000 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Pulmonary Cryptosporidiosis in Simian Immunodeficiency Virus–infected Rhesus Macaques

T. Yanai, L. V. Chalifoux, K. G. Mansfield, A. A. Lackner and M. A. Simon

Abstract

Cryptosporidiosis is a common opportunistic infection in the gastrointestinal tract of human and nonhuman primates with AIDS. Pulmonary infection associated with Cryptosporidium spp. has not been previously reported in monkeys. Two macaques experimentally infected with simian immunodeficiency virus (SIV) had lesions containing cryptosporidial organisms involving the trachea, lungs, bile ducts, pancreas, and intestine. The pulmonary sections revealed moderate to severe bronchopneumonia associated with cryptosporidiosis. Numerous 2–4 µm oval Cryptosporidium spp. organisms were present in the cytoplasm of alveolar macrophages, multinucleated giant cells, and intestinal epithelial cells. Giant cells were positive for SIV by in situ hybridization. These are the first reported cases of cryptosporidiosis with involvement of pulmonary parenchyma in SIV-infected macaques.

Key words: AIDS, Cryptosporidiosis; lung; rhesus macaques; SIV.

Request reprints from Dr. M. A. Simon, Division of Comparative Pathology, New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, P.O. Box 9102, Southborough, MA 01772 (USA).




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