This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Minatel, L. Articles by Carfagnini, J. C. Search for Related Content PubMed PubMed Citation Articles by Minatel, L. Articles by Carfagnini, J. C.

Ceroid-Lipofuscinosis in a Cocker Spaniel Dog

Abstract

A neurodegenerative storage disease identified as ceroid-lipofuscinosis by light, fluorescence, and electron microscopic examinations was diagnosed in a 4-year-old female Cocker Spaniel dog with progressive ataxia and proprioceptive deficits. Stored pigment was found within neurons of the brain and spinal cord and in smooth muscle cells of the urinary bladder and small muscular arteries. The microscopic findings resembled those found in six other cases of generalized ceroid-lipofuscinosis in this breed. However, the brown discoloration of the intestines, which was the major gross lesion observed in those cases, was not found. This is the first report of the disease in Argentina.

Key words: Brown bowel syndrome; ceroid-lipofuscinosis; Cocker Spaniel dogs; electron microscopy; light microscopy.

Request reprints from Dr. L. Minatel, Department of Pathology, Faculty of Veterinary Science, University of Buenos Aires, Av. San Martin 5285, (1417) Capital Federal (Argentina). E-mail: lminatel{at}ciudad.com.ar.

This article has been cited by other articles:

				M. F. Cesta, K. Mozzachio, P. B. Little, N. J. Olby, R. C. Sills, and T. T. Brown Neuronal Ceroid Lipofuscinosis in a Vietnamese Pot-bellied Pig (Sus scrofa). Vet. Pathol., July 1, 2006; 43(4): 556 - 560. [Abstract] [Full Text] [PDF]