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Expression of Cyclooxygenase-2 in Canine Renal Cell Carcinoma

Abstract

Cyclooxygenase-2 (COX-2) has been shown to be the primary enzyme responsible for prostaglandin production during inflammation but is absent in most tissues under normal physiological states. High levels of COX-2 expression have been observed in the macula densa and thick ascending limbs of fetal kidneys; this expression declines to minimal levels during renal maturation. We hypothesized that the neoplastic cells of renal cell carcinoma (RCC) may revert to high expression of COX-2, and we evaluated its expression in three spontaneous cases of canine RCC by using immunohistochemical methods. The neoplastic cells of two of the three cases exhibited moderate to marked COX-2 immunoreactivity. These results suggest that some canine renal cell carcinomas express high levels of COX-2, which may play a role in the modulation of neoplastic cell growth.

Key words: Cyclooxygenase; neoplasms; prostaglandins; renal cell carcinoma.

Request reprints from Kristina M. Stanfield, MS, Searle/Pharmacia, 4901 Searle Parkway J-332, Skokie, IL 60077 (USA).

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