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Vet Pathol 38:119-122 (2001)
© 2001 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Necrotizing Meningoencephalitis Associated with Cortical Hippocampal Hamartia in a Pekingese Dog

C. Cantile, F. Chianini, M. Arispici and R. Fatzer

Abstract

A 4-year-old male Pekingese dog was referred to the clinic with a history of recurrent seizures and progressive abnormal gait and behavior, which did not respond to treatment. At necropsy, a large cortical defect in the right temporo-parietal cortex, malacia of subcortical white matter, right basal nuclei, and capsula interna, as well as abnormalities of the right hippocampus were observed. Histological examination of the brain revealed moderate to severe nonsuppurative meningoencephalitis in the left cerebral hemisphere and extensive infarction-like lesions with milder inflammation in the right hemisphere. In the right hippocampus, the pyramidal cells were arranged in a gyrus-like pattern and intermingled with gemistocytic and fibrillary astrocytes. The histopathological features of the inflammatory lesions were consistent with necrotizing meningoencephalitis and resembled those described in so-called Pug dog encephalitis. The hippocampal changes were interpreted as dysplasia (monolateral hippocampal cortical hamartia), unrelated to clinical signs and necrotizing inflammatory lesions.

Key words: Dysplasia; hamartia; necrotizing meningoencephalitis; Pekingese; Pug dog; encephalitis.

Request reprints from Dr. Carlo Cantile, Dipartimento di Patologia Animale, Facoltà di Medicina Veterinaria, Università degli Studi di Pisa, Viale delle Piagge, 2 I-56124 Pisa (Italy). E-mail: ccantile{at}vet.unipi.it.




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Copyright © 2001 by the American College of Veterinary Pathologists.