Vet Pathol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Madewell, B. R.
Right arrow Articles by Munn, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Madewell, B. R.
Right arrow Articles by Munn, R. J.
Vet Pathol 38:196-202 (2001)
© 2001 American College of Veterinary Pathologists

Feline Vaccine-associated Fibrosarcoma: An Ultrastructural Study of 20 Tumors (1996–1999)

B. R. Madewell, S. M. Griffey, M. C. McEntee, V. J. Leppert and R. J. Munn

Departments of Surgical and Radiological Sciences (BRM, MCM) and Pathology, Microbiology, and Immunology (SMG), School of Veterinary Medicine; Department of Pathology, School of Medicine (RJM); and Department of Chemical Engineering and Materials Science, College of Engineering (VJL), University of California, Davis, CA

Twenty feline vaccine-associated sarcomas were examined by transmission electron microscopy. Tumors contained pleomorphic spindle cells, histiocytoid cells, and giant cells. Most tumors contained myofibroblasts, which had morphologic features similar to those of fibroblasts. These cells were further distinguished by subplasmalemmal dense plaques and thin cytoplasmic actin myofilaments organized as elongated bundles concentrated at irregular intervals forming characteristic dense bodies. Intracellular crystalline particulate material was found in 5 of the 20 tumors. Energy dispersive X-ray spectroscopy was used to identify the crystalline material within one tumor as aluminum-based. One tumor from a feline leukemia virus-infected cat contained budding and immature retroviral particles.

Key words: Feline vaccine-associated sarcoma, ultrastructure.

Request reprints from B. R. Madewell, Department of Surgical and Radiological Sciences, Room 2112, Tupper Hall, University of California, School of Veterinary Medicine, Davis, CA 95616 (USA). E-mail: brmadewell{at}ucdavis.edu.




This article has been cited by other articles:


Home page
 Vet PatholHome page
A. Nieto, M. A. Sanchez, E. Martinez, and E. Rollan
Immunohistochemical Expression of p53, Fibroblast Growth Factor-b, and Transforming Growth Factor-{alpha} in Feline Vaccine-associated Sarcomas
Vet. Pathol., November 1, 2003; 40(6): 651 - 658.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
J. S. Munday, N. L. Stedman, and L. J. Richey
Histology and Immunohistochemistry of Seven Ferret Vaccination-site Fibrosarcomas
Vet. Pathol., May 1, 2003; 40(3): 288 - 293.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
S. S. Couto, S. M. Griffey, P. C. Duarte, and B. R. Madewell
Feline Vaccine-associated Fibrosarcoma: Morphologic Distinctions
Vet. Pathol., January 1, 2002; 39(1): 33 - 41.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American College of Veterinary Pathologists.