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Vet Pathol 38:236-238 (2001)
© 2001 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Immunohistochemical Detection of Tumor Suppressor Gene p53 Protein in Feline Injection Site-associated Sarcomas

P. R. Nambiar, M. L. Jackson, J. A. Ellis, B. J. Chelack, B. A. Kidney and D. M. Haines

Abstract

Sarcomas associated with injection sites are a rare but important problem in cats. Immunohistochemical detection of p53 protein may correlate to mutation of the p53 tumor suppressor gene, a gene known to be important in oncogenesis. The expression of nuclear p53 protein in 40 feline injection site-assocated sarcomas was examined by immunohistochemical staining. In 42.5% (17/40), tumor cell nuclei were stained darkly; in 20% (8/40), tumor cell nuclei were stained palely; and in 37.5% (15/40), tumor cell nuclei were unstained. Immunohistochemical detection of p53 protein in a proportion of injection site-associated sarcomas suggests that mutation of the p53 gene may play a role in the pathogenesis of these tumors.

Key words: Cats; immunohistochemistry; injection-site associated sarcomas; p53.

Request reprints from Dr. D. M. Haines, Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, 57N SB4, Canada. E-mail: hainesd{at}duke.usask.ca.




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Copyright © 2001 by the American College of Veterinary Pathologists.