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Feline Cutaneous Fibropapillomas: Clinicopathologic Findings and Association with Papillomavirus Infection

Department of Veterinary Pathology (FYS) and Department of Cellular Pathology (AEK, TJ), Armed Forces Institute of Pathology, Washington, DC; and Veterinary Division, Marshfield Laboratories, Marshfield, WI (FYS)

Twenty-three feline cutaneous fibropapillomas with histologic features similar to equine sarcoids were diagnosed. They were characterized by dermal fibroblastic proliferation with overlying, often ulcerated hyperplastic epidermis. Electron microscopic findings supported the fibroblastic nature of the neoplastic cells. The 23 tumors came from 20 cats and were submitted from veterinary clinics in Wisconsin and Minnesota. These tumors occurred most commonly in young cats and were found primarily on the head, neck, and digits. Fifteen of the 17 cats for which breed was reported were domestic shorthair cats. In 11/20 cases, there was confirmed exposure to cattle. Local recurrence of the tumor following surgical excision was reported in 7 of the 18 cats for which follow-up information was available. Metastasis was not documented in any of the cases. Two of the 19 tumors tested by polymerase chain reaction (PCR) had no amplifiable DNA. The remaining 17 were positive for papillomavirus by PCR. No papillomavirus DNA was detected in three other feline skin tumors (cutaneous mast cell tumor, malignant lymphoma, and fibrosarcoma) that served as controls. This is the first report of detection of papillomavirus in feline tumors that have clinicopathologic features similar to equine sarcoids.

Key words: Cat; feline; fibropapilloma; papillomavirus; polymerase chain reaction; sarcoid; skin tumor.

Request reprints from Dr. F. Yvonne Schulman, Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000 (USA). Email: schulman{at}afip.osd.mil.

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