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Vet Pathol 38:350-353 (2001)
© 2001 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Bilateral Focal Cerebral Angiomatosis Associated with Nervous Signs in a Cat

A. Kipar, U. Hetzel, A. G. Armien and W. Baumgärtner

Abstract

A case of cerebral angiomatosis in a cat was associated with neurologic signs characterized by clusters of severe generalized seizures. Bilaterally in the gray matter, most prominent in the cingulate gyrus, there was focal accumulation of garlandlike arrangements of blood vessels. Vessels exhibited activated, hypertrophic endothelial cells and thickening and progressive dystrophic mineralization of the basement membrane, with complete luminal obstruction of some affected vessels. Thickening of the basement membrane was due to accumulation of endothelium-derived proteins such as laminin and von Willebrand factor. Furthermore, moderate diffuse astrogliosis was observed. Findings indicate an idiopathic angiomatosis, with clinical signs possibly due to ischemia resulting from narrowing or complete obliteration of vessel lumina. Changes represent a unique endothelial cell–derived lesion within the brain not previously described in humans or domestic animals.

Key words: Brain; cats; cerebral angiomatosis; dystrophic mineralization; electron microscopy; generalized seizures; immunohistology; light microscopy.

Request reprints from Dr. A. Kipar, Institut für Veterinär-Pathologie, Justus-Liebig-Universität Giessen, Frankfurter Strasse 96, D-35392 Giessen, (Germany). Email: anja.kipar{at}vetmed.uni-giessen.de.




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