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Vet Pathol 40:421-432 (2003)
© 2003 American College of Veterinary Pathologists

Immunopathogenesis of Experimentally Induced Proliferative Enteropathy in Pigs

N. MacIntyre, D. G. E. Smith, D. J. Shaw, J. R. Thomson and S. M. Rhind

Department of Veterinary Pathology (NM, SMR) and Centre for Tropical Veterinary Medicine (DJS), Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Midlothian, UK; Department of Medical Microbiology, University of Edinburgh, Teviot Place, Edinburgh, UK (DGES); and Scottish Agricultural College, Bush Estate, Penicuik, Midlothian, UK (JRT)

To characterize the immune response associated with Lawsonia intracellularis infection, twenty-eight, 7-week-old pigs were dosed orally with a pure culture of L. intracellularis. Animals were killed 3, 7, 14, 21, 28, 35, and 42 days postinfection. Light microscopic studies were undertaken to immunophenotype the immunologic response using specific antibodies to T-cell subsets (CD3, CD4, and CD8), B cells, major histocompatibility complex class II, cadherin, and macrophages over the course of time. The results indicate that there is a direct association between the presence of L. intracellularis and reduced T-cell and B-cell numbers. For the first time, this provides evidence of the presence of an immunosuppressive mechanism operating in this disease. Furthermore, macrophage marker studies indicated that macrophages may play a more complex and significant role in the disease process than has been previously reported, with activated macrophages accumulating in infected hyperplastic crypts.

Key words: CD3; immunohistochemistry; macrophages; pigs; proliferative enteropathy.

Request reprints from Dr. S. Rhind, Department of Veterinary Pathology, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Midlothian, EH25 9RG (UK). E-mail: srhind{at}vet.ed.ac.uk.






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