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Vet Pathol 40:556-562 (2003)
© 2003 American College of Veterinary Pathologists

Hepatosplenic Lymphoma in a Dog

M. M. Fry, W. Vernau, P. A. Pesavento, C. Brömel and P. F. Moore

Veterinary Medical Teaching Hospital (MMF, PAP, CB) and Department of Pathology, Microbiology, and Immunology (PFM, WV), School of Veterinary Medicine, University of California, Davis, CA

We describe a case of a dog with hepatosplenic lymphoma, a disease characterized by infiltration of the liver, spleen, and bone marrow with {gamma}{delta} T cells, absence of peripheral lymphadenopathy, and an aggressive clinical course. Physical examination findings, hematologic and biochemical abnormalities, and clinical course of the disease in this patient were similar to those in humans. Immunophenotyping of liver and spleen aspirates supported an antemortem diagnosis of T-cell lymphoma consistent with hepatosplenic lymphoma. The diagnosis was confirmed postmortem by a combination of routine histopathology, showing a consistent pattern of organ involvement, and immunohistochemistry showing the infiltrating neoplastic lymphocytes to be T cells expressing the {gamma}{delta} T-cell receptor. To our knowledge, this is the first reported case of hepatosplenic lymphoma in a dog.

Key words: Canine lymphoma; CD11d; hemophagocytosis; hepatosplenic lymphoma; {gamma}{delta} T cell.

Request reprints from W. Vernau, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616 (USA). E-mail: wvernau{at}ucdavis.edu




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P. F. Moore, V. K. Affolter, and W. Vernau
Canine Hemophagocytic Histiocytic Sarcoma: A Proliferative Disorder of CD11d+ Macrophages.
Vet. Pathol., September 1, 2006; 43(5): 632 - 645.
[Abstract] [Full Text] [PDF]


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