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Vet Pathol 40:567-569 (2003)
© 2003 American College of Veterinary Pathologists
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An Anaplastic Astrocytoma (Optic Chiasmatic-Hypothalamic Glioma) in a Dog

S. Sisó, V. Lorenzo, I. Ferrer, M. Villagrassa and M. Pumarola

Abstract

A tumor located in the optic nerve extended through the optic chiasm, involving the hypophysis and the hypothalamic area in a 3.5-year-old male Boxer dog. It showed a biphasic pattern in which numerous highly fibrillated, well-differentiated pilocytic areas were intermingled with pleomorphic, microcystic tumor tissue. Immunohistochemical analysis of the tumor revealed that most of the neoplastic cells were immunoreactive for S-100 protein, with less intensity for glial fibrillary acidic protein (GFAP) and vimentin. A diagnosis of anaplastic astrocytoma was made on the basis of the histopathologic findings and immunohistochemical results. Moreover, there were similarities with the malignant variant of pilocytic astrocytoma described in human adults as an optic chiasmatic-hypothalamic glioma.

Key words: Anaplastic astrocytoma; dogs; glioma; immunohistochemistry; optic chiasm; optic nerve; pilocytic astrocytoma.

Request reprints from Dr. M. Pumarola, Department of Animal Medicine and Surgery, Veterinary Faculty, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona (Spain). E-mail: marti.pumarola{at}uab.es.






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