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Vet Pathol 40:570-573 (2003)
© 2003 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Polyarteritis Nodosa in a Cynomolgus Macaque (Macaca fascicularis)

B. F. Porter, P. Frost and G. B. Hubbard

Abstract

Polyarteritis nodosa (PAN) is an idiopathic necrotizing vasculitis affecting small- to medium-sized arteries. The disease is well recognized in humans, and PAN-like syndromes have been described in a number of other species. This report describes a case of PAN in a 6-year-old male cynomolgus macaque. The animal had necrotizing arteritis affecting vessels in the kidney, small intestine, colon, heart, spleen, mesentery, urinary bladder, and pancreas. The lesions were segmental in distribution and of varying severity and stage of development. A transmural mixed inflammatory cell infiltrate was present, often accompanied by fibrinoid necrosis of the tunica media and loss of the internal elastic lamina. Immunohistochemical staining showed that many of the infiltrating cells were T lymphocytes and histiocytes, suggesting a cell-mediated component to the pathogenesis.

Key words: Arteries; cardiovascular system; immunohistochemistry; Macaca fascicularis; polyarteritis nodosa.

Request reprints from Dr. G. B. Hubbard, Southwest National Primate Research Center/Southwest Foundation for Biomedical Research, P. O. Box 760549, San Antonio, TX 78245-0549 (USA). E-mail: ghubbard{at}sfbr.org.




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[Abstract] [Full Text] [PDF]


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