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Vet Pathol 41:10-19 (2004)
© 2004 American College of Veterinary Pathologists

Morphology, Immunohistochemistry, and Genetic Alterations in Dog Astrocytomas

G. Stoica, H.-T. Kim, D. G. Hall and J. R. Coates

Departments of Veterinary Pathobiology (GS, H-TK) and Small Animal Medicine and Surgery (JRC), College of Veterinary Medicine, Texas A&M University, College Station, TX; and Texas Veterinary Medical Diagnosis Laboratory (GDH), College Station, TX

Astrocytoma is one of the most common tumors of the central nervous system in animals. Of the domesticated animal species, most examples are seen in dogs, and the spectrum that has been described is quiet broad. Previous studies have revealed morphologic similarities between human and animal astrocytomas. Human astrocytomas are often associated with genetic alterations that determine the clinical behavior and therapy outcome. The purpose of this study was to further characterize astrocytomas in dogs and to determine whether there are genetic changes similar to those in the human counterpart.

Key words: Dog astrocytoma; genetic alterations; morphology.

Request reprints from Dr. G. Stoica, Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4467 (USA). E-mail: gstoica{at}cvm.tamu.edu.




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