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Vet Pathol 41:319-325 (2004)
© 2004 American College of Veterinary Pathologists

Familial Glomerulonephropathy in the Bullmastiff

M. L. Casal, D. M. Dambach, T. Meister, P. F. Jezyk, D. F. Patterson and P. S. Henthorn

Sections of Medical Genetics (MLC, PFJ, DFP, PSH) and Pathology (DMD), and School of Veterinary Medicine (TM), University of Pennsylvania, Philadelphia, PA

Glomerular disease was diagnosed by histopathologic examination in 11 related Bullmastiff dogs, and clinical and laboratory data were collected retrospectively. Four female and seven male dogs between the ages of 2.5 and 11 years were affected. Clinical signs, including lethargy and anorexia, were nonspecific and occurred shortly before death or euthanasia. In five affected dogs serial blood samples were obtained, and dramatically elevated blood urea nitrogen and creatinine levels were demonstrated up to 2.75 years before death. Protein-creatinine ratios were elevated in six of six dogs and were above normal 3.5 years before death in one dog. The kidneys appeared grossly normal to slightly smaller than normal at necropsy. Histologic abnormalities of the kidneys were consistent with chronic glomerulonephropathy with sclerosis. Examination of the pedigrees of related affected dogs yielded evidence supporting an autosomal recessive mode of inheritance.

Key words: Bullmastiffs; dogs; glomerulopathy; glomerulosclerosis; histology; kidney; pathology.

Requests reprints from Dr. M. L. Casal, Section of Medical Genetics, Veterinary Hospital of the University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104–6010 (USA). E-mail: casalml{at}vet.upenn.edu






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