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Well-differentiated Biphasic Synovial Sarcoma in the Atlanto-occipital Joint of a Holstein Cow

Abstract

A 7-year-old Holstein cow developed a large cystic mass in the region between the atlantoaxis and larynx. The mass extended to the synovium in the atlanto-occipital joint. Many villous projections were present on the inner surface of the tumor tissue, and irregular clefts were formed in the inside. Two cell types, epithelioid-like synovioblasts and spindle cells, were present. Immunohistochemical analysis showed that the cells stained positively for cytokeratin (AE1/AE3) and vimentin. Both cells had similar fine structures ultra-structurally. Vacuoles present in the cytoplasm were full of an acid mucous substance. The tumor was diagnosed as a well-differentiated biphasic synovial sarcoma. This is the first report of a rare case of synovial sarcoma, from the viewpoint of its origin.

Key words: Atlanto-occipital joint; cattle; synovial sarcoma; synovioblast.

Request reprints from Dr. T. Oyamada, Department of Veterinary Pathology, Faculty of Veterinary Medicine and Animal Sciences, Kitasato University, 034-8628, Higashi 23-35-1, Towada City, Aomori (Japan). E-mail: oyamd{at}vmas.kitasato-u.ac.jp