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Vet Pathol 42:837-840 (2005)
© 2005 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Erythropoietin Receptor Expression in Canine Mammary Tumor: An Immunohistochemical Study

A. Sfacteria, G. Mazzullo, C. Bertani, P. Calabrò, G. De Vico and B. Macrì

Abstract

Erythropoietin (EPO) is a cytokine primarily involved in the regulation of the erythropoiesis. Recently, it has been demonstrated that EPO and its receptor (EPOR) are expressed in several neoplastic cell lines and solid tumors. Furthermore, in vitro and in vivo studies have shown that EPO could promote human breast carcinoma growth by means of the binding with its receptor, although a clear function for EPO in this setting has not been yet established. While the human medical literature has been accumulating strong evidence on EPO's role in oncogenesis, to date, there are no veterinary reports focusing on such an issue. The aim of the present study was to investigate the immunohistochemical expression of EPOR in canine mammary gland dysplastic and neoplastic lesions. Our results show a weak to moderate EPOR expression in dysplastic glands, being immunoreactivity enhanced as the lesion shows an increasing malignant pattern. On the basis of these findings, this study describes, for the first time, the evidence for EPOR expression in canine mammary gland tumor and suggests a feasible EPO's role for canine mammary tumor progression.

Key words: Dogs; erythropoietin; erythropoietin receptor; mammary gland tumor.

Request reprints from Dr. Alessandra Sfacteria, Department of Veterinary Public Health, Unit of Pathology, Faculty of Veterinary Medicine, University of Messina, 98168, Messina (Italy). E-mail: alesfact{at}yahoo.it






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