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Vet Pathol 43:78-82 (2006)
© 2006 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Characterization of the cDNA Encoding {alpha}IIb and ß3 in Normal Horses and Two Horses with Glanzmann Thrombasthenia

P. W. Christopherson, T. A. Insalaco, V. L. van Santen, L. Livesey, C. Bourne and M. K. Boudreaux

Abstract

Glanzmann thrombasthenia (GT) is an inherited, intrinsic platelet defect characterized by a quantitative or qualitative change in the platelet glycoprotein complex IIb-IIIa (integrin {alpha}IIbß3). The subunits are encoded by separate genes and both subunits must be expressed for a stable complex to form on the platelet surface; therefore, a defect in either gene can result in GT.

Key words: Equine; Glanzmann thrombasthenia; inherited disease; integrin {alpha}IIbß3; platelet; polymerase chain reaction.

Request reprints from Dr. Mary Boudreaux, Department of Pathobiology, 166 Greene Hall, College of Veterinary Medicine, Auburn University, AL 36849-5519 (USA). E-mail: boudrmk{at}auburn.edu






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