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Vet Pathol 43:751-754 (2006)
© 2006 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Nasal Oncocytoma in a Domestic Shorthair Cat

R. W. Doughty, D. Brockman, R. Neiger and L. McKinney

Abstract

An oncocytoma was diagnosed in the nasal cavity of a 12-year-old Domestic Shorthair cat who presented with periocular swelling and sneezing. Histologic examination from biopsy material revealed monomorphic sheets, anastomosing cords, tubules, and acini composed of large polygonal to oval cells that contained abundant finely granular eosinophilic cytoplasm. No vascular or lymphatic invasions were noted. Histochemical stains revealed positive staining of tumor cells with periodic acid–Schiff (PAS) (before and after diastase digestion) and phosphotungstic acid-hematoxylin. Immunohistochemical evaluation of the tumor cells demonstrated positive staining for cytokeratin and negative staining for vimentin, desmin, S-100, glial fibrillar acidic protein, and neuronal specific enolase. Ultrastructurally, the tumor cells contained large numbers of mitochondria within their cytoplasm, which confirmed a diagnosis of oncocytoma.

Key words: Cats; immunohistochemistry; nasal cavity; oncocytoma; ultrastructure.

Request reprints from R W Doughty, PCS Biology, GE Healthcare Bio-sciences, P.O. Box 4220 Nydalen, NO-0401 Oslo, Norway. E-mail: richardwilliam.doughty{at}ge.com






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