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Vet Pathol 44:64-73 (2007)
© 2007 American College of Veterinary Pathologists

Experimental Infection of C3H/HeJ Mice with the NY18 Isolate of Anaplasma phagocytophilum

U. Blas-Machado, J. de la Fuente, E. F. Blouin, C. Almazán, K. M. Kocan and J. V. Mysore4

Department of Veterinary Pathobiology (JF, EFB, CA, KMK), Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ciudad Real, Spain (JF), , 4 , College of Veterinary Medicine, University of Georgia, Athens, GA

Human granulocytic anaplasmosis (HGA), an emerging disease of public health concern in many areas of the world, is caused by Anaplasma phagocytophilum. Small animal models of A phagocytophilum in laboratory mice have been developed and used to study the pathogenesis of HGA. In this study, we characterized the pathologic changes in acute infection of C3H/HeJ mice experimentally infected with the NY18 isolate of A phagocytophilum. Although no clinical signs were noted, acute infection was associated with gross splenomegaly, microscopic inflammatory lesions in the lung and liver, hyperplastic lesions on the spleen, and clinical pathology abnormalities including neutropenia and monocytosis. This study emphasizes the use of well-defined animal models as a valuable tool for the study of A phagocytophilum infections.

Key words: Anaplasma phagocytophilum; animal model; C3H/HeJ mice; human granulocytic anaplasmosis; human granulocytic ehrlichiosis.

Request reprints from Dr. Uriel Blas-Machado, Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA 30602






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