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Solitary Biliary Hamartoma with Cholelithiasis in a Domestic Rabbit (Oryctolagus cuniculus)

Abstract

Hamartomas of the liver and biliary system are extremely rare entities in both animals and humans. Biliary hamartomas in humans are usually multiple and constitute the von Meyenburg complexes. This report describes the presence of a large solitary mass arising from the edge of the right medial liver lobe of a domestic rabbit. Histologically, the mass was composed of an extensive network of large varying sized cystic structures lined by simple cuboidal to columnar epithelium within an abundant fibrous stroma. Within many of the cyst lumina were varying sized, pale white to greenish hard concretions identified as choleliths and were analyzed and found to be composed of calcium carbonate. This is the first known report of biliary hamartoma with cholelithiasis in rabbits.

Key words: Biliary; hamartoma; liver; Oryctolagus; rabbits.

Request reprints from Matthew F Starost, National Institutes of Health, Office of Research Services, Division of Veterinary Resources, Bldg 28A, room 106, 9000 Rockville Pike, Bethesda, MD 20892 (USA). E-mail: starostm{at}mail.nih.gov