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Vet Pathol 45:42-45 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Bilateral Leydig Cell Tumor in a Six-Year-Old Intersex Goat Affected by Polled Intersex Syndrome

L. V. Monteagudo, M. V. Arruga, J. I. Bonafonte, M. OrdÁs, A. Whyte, M. Gallego, J. A. Bascuas and I. Sierra

Laboratory of Cytogenetics and Molecular Genetics (LVM, MVA), Department of Animal Pathology (JIB, MO, AW, MG, JAB), and Department of Animal Productions and Food Technology (IS), University of Zaragoza, Faculty of Veterinary Science, Zaragoza, Spain

Abstract

A 6-year-old, sterile, Blanca Celtibérica breed adult doe was referred to our faculty. The doe had external female genitalia, a short anogenital distance, and normally shaped udders. Masculinization signs in the head shape and male behavior were also noted at the time of referral. Genetic analysis demonstrated normal 2n = 60 XX karyotype and an absence of the sex-determining region Y (SRY). The animal was homozygous for a DNA deletion responsible for the Polled Intersex Syndrome (PIS). A uterus and 2 uterine horns were present at the postmortem examination. Gartner's ducts and degenerated Wolffian derivatives persisted. There were 2 intra-abdominal testicle-like structures, one of which consisted of epididymal and deferent ducts. An advanced Leydig cell tumor, resulting in almost total destruction of the intratesticular structures, was also observed. Leydig cell tumors usually produce testosterone. Thus, these histologic findings are compatible with the evident virilization.

Key words: Goats; Leydig cell tumor; male pseudohermaphrodite; Polled Intersex Syndrome.

Request reprints from Dr. L V Monteagudo, Laboratorio de Citogenética y Genética Molecular, Facultad de Veterinaria, Universidad de Zaragoza, C/ Miguel Servet 177, 50013-Zaragoza (Spain). E-mail: monteagu{at}unizar.es






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