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B-Cell Lymphoma in the Peripheral Nerves of a Cat

Department of Small Animal Clinical Sciences (MAH, JHR) and Department Biomedical Sciences and Pathobiology (GKS), Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech University, Blacksburg, VA; and Department of Pathobiology and Diagnostic Investigations, Diagnostic Center for Population and Animal Health, Michigan State University, Lansing, MI(SH, MK)

Abstract

A B-cell, Burkitt-type lymphoma, diffusely affecting the peripheral nerves and intramuscular nerve branches was diagnosed in a 4-year-old domestic shorthair cat with a chronic progressive history of flaccid tetraparesis and generalized muscle atrophy. There was no evidence of cranial nerve, central nervous system, radicular, bone marrow, splenic, or lymph node involvement. The cat tested negative for feline retroviruses and a wide variety of herpes viruses, including Epstein-Barr virus. The clinical manifestation of this case was similar to the chronic polyneuropathic variant of human diffuse neurolymphomatosis; a condition most commonly caused by an axonopathy resulting from infiltration of peripheral nerves with non-Hodgkin's lymphoma.

Key words: B-cell; Burkitt-type; feline; lymphoma; peripheral nerve.

Request reprints from Dr. J H RossmeislJr., Department of Small Animal Clinical Sciences, Mail Code 0442, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech University, Blacksburg, VA 24061. E-mail: jrossmei{at}vt.edu