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Granular Cell Tumor in the Testis of a Rabbit: Cytologic, Histologic, Immunohistochemical, and Electron Microscopic Characterization

Toxicology and Drug Disposition, Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, IN (ARI), the Avian and Exotic Animal Clinic of Indianapolis, Indianapolis, IN (AML), and the Department of Comparative Pathobiology, Purdue University, West Lafayette, IN (JAR)

Abstract

An adult pet rabbit (Oryctolagus cuniculus) presented with a progressively enlarging left testicle. Because neoplasia was suspected, the testicle was removed. Pathologic evaluation (exfoliative cytology, histopathology, immunohistochemistry, electron microscopy) indicated that the tumor was an intratesticular granular cell tumor. Granular cell tumor has not been described in rabbits before and has not been described in the testes of animals or postnatal humans. Granular cell tumor should be included as a differential diagnosis of testicular tumors, particularly Leydig cell tumor, because of potential histologic similarities.

Key words: Cytology; electron microscopy; granular cell tumor; histology; immunohistochemistry; Leydig cell tumor; rabbits; testes.

Armando R. Irizarry-Rovira, Toxicology and Drug Disposition, Lilly Research Laboratories, a Division of Eli Lilly and Company, Greenfield, IN 46140 (USA). E-mail: irizarryar{at}lilly.com