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Vet Pathol 45:201-202 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Sphingomyelinase Deficiency (Niemann-Pick disease) in a Hereford Calf

G. K. Saunders and D. A. Wenger

College of Veterinary Medicine, Virginia Tech, Blacksburg, VA (GKS), and Department of Neurology, Jefferson Medical College, Philadelphia, PA (DAW)

Abstract

A 5-month-old Hereford calf with neurologic disease was euthanatized, and a necropsy was done. No gross lesions were seen in the brain. Microscopically, neurons throughout the brain and spinal cord had distended, foamy vacuolated cytoplasm. Ultrastructure showed clear vacuoles filling the neuronal cytoplasm. A lysosomal storage disease was suspected. Sphingomyelinase deficiency was confirmed by biochemical analysis of liver and brain.

Key words: Bovines; brain; lysosomal storage; neuron; Niemann-Pick; sphingomyelinase.






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