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Vet Pathol 45:226-231 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Multisystemic Abscesses in African Green Monkeys (Chlorocebus aethiops) with Invasive Klebsiella pneumoniae—Identification of the Hypermucoviscosity Phenotype

N. A. Twenhafel, C. A. Whitehouse, E. L. Stevens, H. E. Hottel, C. D. Foster, S. Gamble, S. Abbott, J. M. Janda, N. Kreiselmeier and K. E. Steele

US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD (NAT, CAW, ELS, HEHCDF, SG, NK, KES), and Microbial Diseases Laboratory, Division of Communicable Diseases, California Department of Health Services, Richmond, CA (SA, JMJ)

Abstract

Invasive Klebsiella pneumoniae is an emerging disease of humans characterized by abscesses in the liver or other sites involving bacteria with the unique hypermucoviscosity phenotype. Over several months, 7 African green monkeys in our research colony developed abscess formation in multiple locations and succumbed to disease. K. pneumoniae was identified by bacterial culture in 6 monkeys and immunohistochemistry in 1 additional monkey. All monkeys had been housed in, or had contact with monkeys housed in, 1 animal room in our facility. All affected monkeys had 1 or more abscesses, most notably in the abdomen, but also affecting the lungs, cerebellum, and skin. Abdominal abscesses and associated adhesions entrapped loops of bowel, forming palpable masses. Abdominal masses were located at the root of the mesentery, the ileocecocolic junction, or the pelvic inlet. In 1 case, culture, serotyping, and polymerase chain reaction (PCR) analysis of the bacterial isolate identified K. pneumoniae expressing the hypermucoviscosity phenotype and capsular serotype K2 and determined that the K. pneumonia was genetically rmpA+/magA–.

Key words: Abscess; African green monkeys; hypermucoviscosity; invasive; Klebsiella pneumoniae.






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