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Vet Pathol 45:232-235 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Congenital Cystic Adenomatoid-like Malformation in a Cynomolgus Monkey (Macaca fascicularis)

S. Okabayashi, C. Ohno, M. Kato, H. Nakayama and Y. Yasutomi

Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Ibaraki, Japan (SO, CO, MK, YY), The Corporation for Production and Research of Laboratory Primates, Ibaraki, Japan (SO, CO, MK), 3 and the Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan (HN)

Abstract

Congenital cystic adenomatoid malformation (CCAM) is a developmental lung abnormality characterized by abnormal proliferation of mesenchymal elements and failure of bronchiolar structures to mature, ultimately resulting in the compression of normal pulmonary tissue and mediastinal shift with rapid expansion of cysts. Although various clinical and pathologic studies of CCAM in humans exist, CCAM has yet to be reported in animals, even in nonhuman primates. In the present study, histopathologic analyses of a neonatal cynomolgus monkey that died 17 days after birth revealed that normal lung architecture was replaced by disorganized overgrowths of cysts lined with simple cuboidal epithelium. The epithelium projected a few ciliates into the air spaces and produced mucus. To our knowledge, this is the first case study describing CCAM or a CCAM-like lesion in nonhuman primates.

Key words: Congenital cystic adenomatoid malformation; cynomolgus monkey; histopathological analyses; lung.

Request reprints from S Okabayashi, The Corporation for Production and Research of Laboratory Primates, Hachimandai 1-1, Tsukuba-shi, Ibaraki 305-0843 (Japan). E-mail: okarin{at}primate.or.jp






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