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Vet Pathol 45:455-466 (2008)
© 2008 American College of Veterinary Pathologists
IMMUNOINFLAMMATORY, DEGENERATIVE, NUTRITIONAL, TRAUMATIC, AND GENETIC DISEASES

Complementary Distributions of Amyloid-β and Neprilysin in the Brains of Dogs and Cats

Y. Takeuchi, K. Uetsuka, M. Murayama, F. Kikuta, A. Takashima, K. Doi and H. Nakayama

Department of Veterinary Pathology,, Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo ku, Tokyo, Japan (YT, KU, KD, HN);, Laboratory for Alzheimer's Disease, Brain Science Institute, RIKEN, Wako-shi, Saitama, Japan (MM, AT), St. Luke's College of Nursing,, Chuou-ku, Tokyo, Japan (FK)

Abstract

Neprilysin is an amyloid-β-degrading enzyme localized in the brain parenchyma. The involvement of neprilysin in the pathogenesis of Alzheimer's disease has recently received much attention. We examined the localization of neprilysin and amyloid-β, as well as the activity of neprilysin, in the brains of dogs and cats of various ages to clarify the relationship between neprilysin activity and amyloid-β deposition. The distribution of neprilysin was almost identical in dogs and cats, being high in the striatum, globus pallidus, and substantia nigra, but very low in the cerebral cortex. The white matter and hippocampus were negative. Neprilysin activity in the brain regions in dogs and cats was ranked from high to low as follows: thalamus/striatum > cerebral cortex > hippocampus > white matter. Amyloid-β deposition was first detected at 7 and 10 years of age in dogs and cats, respectively, and both the quantity and frequency of deposition increased with age. In both species, amyloid-β deposition appeared in the cerebral cortex and the hippocampus. In summary, the localization of neprilysin and neprilysin activity, and that of amyloid-β, were complementary in the brains of dogs and cats.

Key words: Aging; amyloid-β; brain; cat; neprilysin.

Request reprints from Dr. Yoshinori Takeuchi, Department of Veterinary Pathology, Graduate School of Agricultural and Life Science, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113-8657, (Japan). E-mail: ytake-tky{at}umin.net






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