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Diagnostic Exercise: Papulovesicular Dermatitis in Rhesus Macaques (Macaca mulatta)

Department of Genetics, University of Alabama at Birmingham, Birmingham, AL (TRS, SCC), Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, OK (RE, DHB), and RFP Consulting LLC Ann Arbor, MI (RFP)

Abstract

Eleven rhesus monkeys developed multifocal erythematous and a vesicular rash. Most recovered spontaneously, but a 21-year-old female became moribund and was euthanized. Findings were of vesicular dermatitis and widespread multifocal hemorrhagic necrosis of the lungs and other viscera, with intralesional intranuclear inclusions. Simian varicella virus was identified as the cause by polymerase chain reaction analysis and serologic testing.

Key words: Dermatitis; Macaca mulatta; pneumonia; varicellovirus.

Request reprints from Trenton R Schoeb, UAB Department of Genetics, 724 Kaul Human Genetics Bldg., 720 S. 20th St., Birmingham, AL 35294 (USA). E-mail: trs{at}uab.edu